Here is a post to share your favorite difficulties settings.
The normal game give 12/24/36/48 elo for a win.
The most popular change is '+10 health' which increase slightly the difficulty but give more time to setup everything: +50% boost in elo.
My favorite which give a totally new playstyle is: -2 atk / max combo 18 (so you can pair 666) / remove 8~10 which play more around doing pairs and create a constant difficulty instead of having Kings being the hardest in the normal game: it give 59 elo at 2 players.
What is the setup you like?