Problems as I see them:
1) The HR is terrible. You buy a new room, but getting someone there could take 2-3 HR turns. Even if you do, most new rooms make you eject to use the room, so in a game you'll get one, maybe two uses out of it. It's just not worth it (which is what I think causes the tech zerg, which makes sense).
2) The Railroads seem to matter far more than anything else. As per 1) above, just kick out a guy to the game board and have them sit there and actually collect stuff. Now the collection is almost 100% turn-based and has nothing to do with your industry (in an industry-building game).
3) Spiteful turns. If you don't want HR moves, simply pick them too early, and now points 1) and 2) above become borderline impossible to do.
This is just me and I know many here will disagree with me, but from my point of view, I'd love to love this game as it looks like a lot of fun, but it just wasn't when I actually played it. I will watch it though, see what changes happen.