Yes! According to the rules, you get zero points against players who are more than 2 leagues away from you. https://boardgamearena.com/faq?anchor=f ... renaworks2
You can, however, restrict your possible opponents to leagues close to your one. Click the cogwheel next to the game icon in the lobby, -> Extended Options -> Opponent level.
I think you are the 251364th person to raise this question. Why a restrcted opponent level is not the default for 2p games or why the setting is hidden so deeply in the interface? These are question far beyond human comprehension and they remain open riddles of the human race.